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目的探讨托吡酯对癫痫的治疗效果及安全性情况,以促进临床合理用药。方法回顾性分析143例癫痫患者的临床资料,均给予托吡酯单药治疗,并观察用药后癫痫发作情况及不良反应。结果托吡酯治疗癫痫的总有效率为77.6%。其中,单纯部分性发作的总有效率(95.0%)明显高于复杂部分性发作(63.0%)、全面性发作(77.2%),且差异均有统计学意义(P<0.05)。少数患者出现记忆力下降、体重减轻、言语障碍、嗜睡、恶心、头昏、头昏等不良反应,全部出现在加量期,后未经特殊处理,症状均自行消失。同时治疗前后患者的血、尿常规、肝、肾功能等检查结果均无明显变化。结论托吡酯治疗癫痫的临床效果好,无严重不良反应,安全性高,故可作为一线抗癫痫药单独使用。
Objective To investigate the therapeutic effect and safety of topiramate on epilepsy in order to promote clinical rational use of drugs. Methods The clinical data of 143 epileptic patients were retrospectively analyzed. Topiramate monotherapy was given. The seizure status and adverse reactions were observed after treatment. Results The total effective rate of topiramate treatment of epilepsy was 77.6%. The total effective rate (95.0%) of simple partial seizures was significantly higher than that of complicated partial seizures (63.0%) and comprehensive seizures (77.2%), with statistical significance (P <0.05). A small number of patients with memory loss, weight loss, speech disorders, lethargy, nausea, dizziness, dizziness and other adverse reactions, all appear in the amount of period, without special treatment, the symptoms disappear on their own. At the same time before and after treatment of patients with blood, urine, liver, kidney function test results showed no significant change. Conclusion Topiramate treatment of epilepsy clinical effect, no serious adverse reactions, high safety, it can be used as first-line antiepileptic drugs alone.