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目的探讨血清血管内皮细胞生长因子(VEGF)和超敏C反应蛋白(hs-CRP)在子宫内膜异位症中的临床应用价值。方法采用酶联免疫法(ELISA)测定36例重度子宫内膜异位症患者在GnRHa联合反向添加治疗前后血清VEGF和hs-CRP含量的变化,并与24例健康人(对照组)进行比较。结果治疗前子宫内膜异位症患者血清VEGF和hs-CRP的含量均明显高于对照组(均P<0.01),经GnRHa联合反向添加治疗6个月后血清中VEGF和hs-CRP的含量均明显下降(均P<0.01)。治疗前子宫内膜异位症患者血清VEGF和hs-CRP含量呈明显正相关(P<0.05)。结论血清VEGF和hs-CRP水平的变化能快速反映子宫内膜异位症患者子宫内膜血管生成和炎症反应的程度,GnRHa联合反向添加治疗能有效地改善子宫内膜异位的血管生成和炎症反应。
Objective To investigate the clinical value of serum vascular endothelial growth factor (VEGF) and high sensitivity C-reactive protein (hs-CRP) in endometriosis. Methods Serum levels of VEGF and hs-CRP were measured in 36 patients with severe endometriosis by enzyme-linked immunosorbent assay (ELISA) before and after GnRHa plus reverse addition, and compared with 24 healthy people (control group) . Results The levels of serum VEGF and hs-CRP in patients with endometriosis before treatment were significantly higher than those in the control group (all P <0.01). The levels of VEGF and hs-CRP in serum after 6 months of treatment with GnRHa plus reverse addition Content were significantly decreased (all P <0.01). The levels of serum VEGF and hs-CRP in patients with endometriosis before treatment were positively correlated (P <0.05). Conclusions The changes of serum VEGF and hs-CRP levels can quickly reflect the degree of endometrial angiogenesis and inflammatory reaction in endometriosis patients. GnRHa combined with reverse addition therapy can effectively improve the angiogenesis of endometriosis and Inflammation.