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拘束负荷动物表现出的应激反应可以部分描述心理应激状态,可以在多靶点整体动物水平上进行观察,在药理学、生理学及病理学等多种研究领域被国内外广泛应用。本文介绍了拘束应激模型的发展历史,概述了国内外有关模型的制作及模型影响因素,综述拘束应激对机体的影响及作用机制,同时结合我们的实际经验提出该模型存在的问题,并对其研究应用前景进行展望。
The stress response exhibited by the restrained animals can partly describe the state of psychological stress, and can be observed at the multi-target whole animal level. It is widely used in many fields such as pharmacology, physiology and pathology. This article introduces the history of the development of restraint stress model, summarizes the domestic and international related model making and the influencing factors of the model, summarizes the influence and action mechanism of restraining stress on the body, and puts forward the problems in this model according to our practical experience Prospects for its research and application prospects.