论文部分内容阅读
目的探讨益生菌对小儿炎性反应调控及肠道屏障保护作用。方法将124例顽固性腹泻患儿随机分为对照组62例以及观察组62例,对照组患儿口服蒙脱石散治疗,观察组患儿在对照组的基础上口服金双歧杆菌,用药7 d后对比分析2组治疗情况。结果观察组总有效率为95.16%,对照组总有效率为75.80%,2组总有效率差异有统计学意义(χ2=3.992,P=0.002)。观察组治疗后第3天、第7天乳酸杆菌、双歧杆菌、大肠埃希菌数量显著高于对照组(P<0.05)。观察组治疗后血DAO、血D-乳酸、IL-1、IL-6、TNF-α水平显著低于对照组(P<0.05)。结论金双歧杆菌复方合剂能有效改善小儿肠道菌群平衡及肠道屏障功能,调节机体免疫水平,提高小儿顽固性腹泻的治疗效果。
Objective To investigate the effect of probiotics on the inflammatory response in children and the protective effect of intestinal barrier. Methods Totally 124 children with intractable diarrhea were randomly divided into control group (n = 62) and observation group (n = 62). The control group was treated with montmorillonite powder. The patients in the observation group were given oral Bifidobacterium bifidum on the basis of the control group, After comparative analysis of two groups of treatment. Results The total effective rate was 95.16% in the observation group and 75.80% in the control group. The total effective rate in the two groups was statistically significant (χ2 = 3.992, P = 0.002). The number of Lactobacillus, Bifidobacterium and Escherichia coli in the observation group was significantly higher than that of the control group on the 3rd and the 7th day after treatment (P <0.05). The blood levels of DAO, blood D-lactate, IL-1, IL-6 and TNF-α in the observation group were significantly lower than those in the control group (P <0.05). Conclusion Bifidobacterium complex compound can effectively improve children’s intestinal flora balance and intestinal barrier function, regulate body immunity and improve refractory diarrhea in children.