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目的探讨人脑胶质瘤的细胞增殖指数(PI)和微血管数(MVQ)与肿瘤病理分级的关系。方法采用免疫组化方法检测50例人脑胶质瘤的增殖细胞核抗原(PCNA)及CD34的表达,计算PI和MVQ,比较PI和MVQ与脑胶质瘤病理学分级之间的关系。结果随着脑胶质瘤病理级别的升高,PI及MVQ随之升高。Ⅰ～Ⅳ级病理分组中,除Ⅰ级与Ⅱ级间比较无差异,其余各级间比较PI和MVQ均有显著差异,且PI与MVQ呈正相关(r=0.855,P<0.05)。结论人脑胶质瘤的细胞增殖指数和微血管数可以作为判定脑胶质细胞瘤病理级别及预后的有价值参考指标。
Objective To investigate the relationship between the proliferation index (PI) and the number of microvessel (MVQ) in human glioma and the pathological grade of tumor. Methods Immunohistochemistry was used to detect the expression of proliferating cell nuclear antigen (PCNA) and CD34 in 50 human gliomas. The PI and MVQ were calculated. The relationship between PI and MVQ and pathological grading of glioma was compared. Results With the pathological grade of glioma increased, PI and MVQ increased accordingly. There was no significant difference between grade I and grade IV in grade I and grade II, but PI and MVQ in other grades were significantly different. There was a positive correlation between PI and MVQ (r = 0.855, P <0.05). Conclusions The cell proliferation index and microvessel number of human glioma can be used as a valuable reference to judge the pathological grade and prognosis of glioma.