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[目的]探讨细胞因子诱导杀伤细胞(CIK细胞)在消化道癌中的疗效。[方法]选取2008年9月~2010年6月于本院进行治疗的88例消化道癌患者为研究对象,将其随机分为对照组(化疗组)44例和观察组44例,后将两组患者的不良反应发生率、SF-36总分及治疗前后的外周血T淋巴细胞亚群、血清CA199、CA242、CEA、AFP及CA724水平进行统计及比较。[结果]观察组的不良反应发生率低于对照组,SF-36总分高于对照组,CD3、CD4、++CD4/CD8水平高于对照组,CD8水平低于对照组,血清CA199、CA242、CEA、AFP及CA724水平均低于对照组,P﹤+++0.05或P﹤0.01,差异有统计学意义。[结论]CIK细胞在消化道癌的中的疗效较佳,值得推广应用。
[Objective] To investigate the efficacy of cytokine-induced killer cells (CIK cells) in gastrointestinal cancer. [Methods] A total of 88 patients with gastrointestinal cancer treated in our hospital from September 2008 to June 2010 were selected and randomly divided into control group (44 cases) and observation group (44 cases) The incidence of adverse reactions, the total score of SF-36 and the levels of peripheral blood T lymphocyte subsets, serum CA199, CA242, CEA, AFP and CA724 in two groups were compared and statistically analyzed. [Results] The incidence of adverse reactions in the observation group was lower than that of the control group, the total score of SF-36 was higher than that of the control group, the levels of CD3, CD4 and ++ CD4 / CD8 were higher than those in the control group, CA242, CEA, AFP and CA724 levels were lower than the control group, P <+++ 0.05 or P <0.01, the difference was statistically significant. [Conclusion] CIK cells have better curative effect in digestive tract cancer, which is worth popularizing and applying.