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目的探讨消化性溃疡患者血浆内皮素测定的临床意义。方法采用放射免疫法分别测定２１例胃溃疡、３０例十二指肠球部溃疡患者和２０例正常对照者血浆内皮素值，并应用ＳＡＳ电脑软件进行统计处理。结果胃溃疡组血浆内皮素值为：（８４．２８±１８．７６）ｐｇ／ｍｌ，球部溃疡组血浆内皮素为：（８７．６７±２０．３５）ｐｇ／ｍｌ，与正常对照组比较，差异均有显著性（Ｐ＜０．００１），胃溃疡组与球部溃疡组比较差异无显著性（Ｐ＞０．０５）。结论血浆内皮素与消化性溃疡的发生有较密切的关系。
Objective To investigate the clinical significance of plasma endothelin in patients with peptic ulcer. Methods Plasma endothelin levels were measured by radioimmunoassay in 21 gastric ulcer patients, 30 duodenal ulcer patients and 20 normal controls. SAS software was used for statistical analysis. Results Plasma endothelin level in gastric ulcer group was (84.28 ± 18.76) pg / ml, plasma endothelin level in ulcer group was (87.67 ± 20.35) pg / ml, which was significantly higher than that in normal control group (P <0.001). There was no significant difference between ulcer group and gastric ulcer group (P> 0.05). Conclusion Plasma endothelin and peptic ulcer are closely related.