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各种原因引起的慢性肾病最终都不可避免地引起慢性肾衰(CRF)。肾脏病慢性进展的机制至今仍不十分清楚。近年来许多研究提示慢性肾病存在的肾小球毛细血管高血压、高滤过、高灌注状态可能是促使肾小球硬化、肾功能进一步恶化的重要因素。随着对血管紧张素Ⅱ(angiotensinⅡAⅡ)在调节肾小球血流动力学中作用认识的深入,人们推测转换酶抑制剂(Converting enzyme inhibitor CEI)可能通过其独特的降低肾小球毛细血管血压而延缓CRF进展,因而对CEI在延缓CRF进展中的作用进行了许多实验和临床研究,本文简要综述CEI治疗慢性肾病的研究现状。
Chronic kidney disease caused by various causes will inevitably lead to chronic renal failure (CRF). The mechanism of chronic kidney disease is still not clear. In recent years, many studies suggest that glomerular capillary hypertension, hyperfiltration and hyperperfusion in chronic kidney disease may be an important factor to promote glomerular sclerosis and further worsen renal function. With the deepening understanding of the role of angiotensin II AII in the regulation of glomerular hemodynamics, it has been speculated that Converting enzyme inhibitor (CEI), through its unique ability to reduce glomerular capillary blood pressure Delay the progress of CRF, and thus carry out many experimental and clinical studies on the role of CEI in delaying the progression of CRF. This article briefly reviews the research status of CEI in the treatment of chronic kidney disease.