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在３８．５±０．１℃，硝酸钾维持离子强度为０．１的条件下，用ｐＨ电位滴定法测定了一种解毒健脾中药有效成分与铅、镉、汞等离子形成的各种配合物的表观稳定常数，得到了在不同ｐＨ条件下该中药与金属离子混合体系中各配合物组分的物种分布图．发现在与人体生理ｐＨ相近的条件下，该中药与铅、镉、汞等离子有良好的结合能力，其排除体内有毒重金属的效果远好于传统的ＥＤＴＡ－Ｚｎ盐，并且对体内必需微量元素Ｚｎ的存在不会产生明显的影响．从配位化学角度对该中药在临床上的有效促排有毒重金属现象从理论上作出了解释
Under the conditions of 38.5 ± 0.1 ℃ and potassium nitrate maintaining ionic strength of 0.1, various combinations of active ingredients of detoxification and invigorating spleen medicine and ions of lead, cadmium and mercury were determined by pH potentiometric titration The apparent stability constants of the compounds were obtained, and the species distribution profiles of the complexes in the mixture of Chinese medicine and metal ions were obtained under different pH conditions. It is found that the Chinese medicine has good binding ability with lead, cadmium and mercury ions under the similar physiological physiological pH. The effect of eliminating toxic heavy metals in the body is much better than that of the traditional EDTA-Zn salt, and the essential Zn The existence will not have a significant impact. From the coordination chemistry point of view of the Chinese medicine in the effective promotion of toxic and heavy metals in the clinical interpretation of a theoretical explanation