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目的:探讨慢性阻塞性肺疾病(COPD)患者血清C反应蛋白、白细胞介素-6、γ-干扰素的水平变化及相关性,研究它们在COPD发病机制中的作用及意义。方法:分别采集来本院治疗的慢性阻塞性肺疾病急性加重期、治疗后稳定期患者以及健康者外周血,采用ELISA法检测血清IL-6、INF-γ、CRP水平。结果:急性加重期组血清IL-6、INF-γ、CRP水平远远高于治疗后稳定期组,而治疗后稳定期组则明显高于健康对照组,差异均有显著性(P<0.05)。结论:COPD患者血清IL-6、INF-γ、CRP的水平与病情变化密切相关,血清IL-6、INF-γ、CRP水平的变化可以作为衡量COPD病情严重程度的指标之一。
Objective: To investigate the changes and correlations of serum C-reactive protein, interleukin-6 and interferon-γ in patients with chronic obstructive pulmonary disease (COPD) and their roles in the pathogenesis of COPD. Methods: Serum levels of IL-6, INF-γ and CRP were measured by ELISA in patients with acute exacerbation of chronic obstructive pulmonary disease, stable patients after treatment, and healthy controls respectively. Results: Serum levels of IL-6, INF-γ and CRP in acute exacerbation group were significantly higher than those in stable group after treatment, while those in stable group were significantly higher than those in healthy control group (P <0.05 ). CONCLUSIONS: The levels of IL-6, INF-γ and CRP in patients with COPD are closely related to the changes of the disease. The changes of serum IL-6, INF-γ and CRP levels may be used as one of the indicators to evaluate the severity of COPD.