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36岁男性,因脱发每日自行煎服制何首乌15 g,服用第23天时又饮黄酒500 ml,饮酒次日发现皮肤黄染,仍继服制何首乌7天后因“皮肤黄染1周”入院。入院前查总胆红素、直接胆红素、丙氨酸氨基转移酶、天冬氨酸氨基转移酶、碱性磷酸酶、谷氨酰转肽酶均较正常范围显著升高。临床诊断为肝功能异常,药物性肝损害可能。《中华人民共和国药典2015年版一部》中制何首乌的每日用量规定为6~12 g,结合患者发病情况进行分析,认为该患者为超剂量长时间用药加饮酒共同作用致肝损害。提示今后在报告药源性损害时,应详尽调查、具体分析,说明相关因素,避免得出以偏概全的结论。
36-year-old man due to hair loss decoction daily self-serving Polygonum 15 g, take the first 23 days and then drink rice wine 500 ml, drinking the next day found that the skin yellow dye, is still following the system Polygonum 7 days later due to “skin yellow dye 1 week ”Admitted to hospital. Before admission, total bilirubin, direct bilirubin, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, glutamyl transpeptidase were significantly higher than the normal range. Clinical diagnosis of abnormal liver function, drug-induced liver damage may be. “The People’s Republic of China Pharmacopoeia 2015 edition of a” system of Chinese fleece-flower daily dosage requirements of 6 ~ 12 g, combined with the incidence of patients analyzed, that the patients overdose for a long time combined with alcohol consumption caused by liver damage. Prompted future reports of drug-induced damage should be investigated in detail, the specific analysis, explain the relevant factors, to avoid the conclusion to the more general.