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目的:比较甘氨双唑钠与顺铂在鼻咽癌放疗中的增敏作用。方法:将2008年1月-2010年6月于我院进行治疗的58例鼻咽癌患者随机均分为A、B组,2组分别在放疗的同期采用甘氨双唑钠或顺铂进行配合用药,治疗后比较2组患者的治疗总有效率和不良反应发生率以及治疗前、治疗后1个月及3个月的血清细胞角蛋白19片段(Cy211)、癌胚抗原(CEA)、肿瘤特异性生长因子(TSGF)、血管内皮生长因子(VEGF)水平。结果:A组的治疗总有效率高于B组,不良反应发生率低于B组,治疗后1个月及3个月的血清Cy211、CEA、TSGF、VEGF水平均低于B组,差异有统计学意义(P<0.05或P<0.01)。结论:甘氨双唑钠在鼻咽癌放疗中的增敏作用优于顺铂,不良反应较低,综合优势明显。
OBJECTIVE: To compare the sensitizing effects of glycidodazole and cisplatin in radiotherapy of nasopharyngeal carcinoma. Methods: 58 patients with nasopharyngeal carcinoma treated in our hospital from January 2008 to June 2010 were randomly divided into A and B groups. The two groups were treated with sodium glycididazole or cisplatin respectively during the same period of radiotherapy. After treatment, the total effective rate of treatment and the incidence of adverse reactions were compared between the two groups before treatment, at 1 month and 3 months after treatment, the serum cytokeratin 19 fragment (Cy211), carcinoembryonic antigen (CEA) Tumor-specific growth factor (TSGF), vascular endothelial growth factor (VEGF) levels. Results: The total effective rate of treatment group A was higher than that of group B, and the incidence of adverse reactions was lower than that of group B. The serum levels of Cy211, CEA, TSGF and VEGF at 1 month and 3 months after treatment were lower than those in group B Statistical significance (P <0.05 or P <0.01). CONCLUSIONS: The sensitizing effect of glycididazole sodium in radiotherapy of nasopharyngeal carcinoma is better than that of cisplatin, the adverse reaction is low, and the comprehensive advantages are obvious.