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一、麻风 麻风病的预防和根治一直是临床传染病学中的棘手问题之一。Halmes体外试验发现,利福平(RFP)对麻风杆菌有强大的杀灭作用,尤其对神经有很强的穿透务。血药浓度0.9μg/ml即可抑制该菌。英国近年来推荐了以RFP为主加砜炎的快速复合疗法,认为RFP+氨苯砜及=乙酰氨苯砜可万无一失地收到高效快速的结果。传染性瘤型麻风成人用600mg/d×7d可杀灭99.9％的麻风杆菌。残留的极少数抗药株可用0.1/d氨苯砜杀灭。一般合用二药1～2周即可解除隔离。目前认为RFP类在麻风的防治中是一个极有前途的药物其更恰当的疗程正在深入观察。
First, the prevention and cure of leprosy has always been one of the thorny problems in clinical epidemiology. Halmes in vitro tests found that rifampin (RFP) has a strong killing effect on M. leprae, especially for nerve penetration. Blood concentration of 0.9μg / ml to inhibit the bacteria. In recent years, the UK has recommended a rapid combination therapy based on RFP and sulfonylurea. It believes that RFP + dapsone and = acetaminophen can safely and quickly receive efficient and rapid results. Infectious nodules leprosy adult with 600mg / d × 7d kill 99.9% of leprosy. Residual few resistant strains can be 0.1 / d dapsone to kill. General joint two drugs can be released within 1 to 2 weeks. It is currently believed that RFP is a promising drug in the prevention and treatment of leprosy. Its more appropriate course of treatment is undergoing in-depth observation.