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目的:探讨用亚砷酸、全反式维甲酸与化疗药物综合治疗急性早幼粒细胞白血病(APL)的疗效及转归,观察使用亚砷酸对APL近期和远期疗效的影响。方法:对初治或复治的APL12例,先用亚砷酸或全反式维甲酸诱导缓解,再用亚砷酸、全反式维甲酸和化疗药物序贯交替治疗,持续缓解5 a以上者停药观察;以同期未用亚砷酸治疗的20例作对照。结果:治疗组CR为100%,3 a CCR为75 %,5 a CCR为50 %,明显优于对照组。结论:该方案治疗APL能获得较高的缓解率和长期生存率,并提示无论诱导或缓解后用亚砷酸治疗APL均有价值。
Objective: To investigate the efficacy and outcome of combined treatment of arsenite, all-trans retinoic acid and chemotherapeutic agents in the treatment of acute promyelocytic leukemia (APL) and to investigate the effects of arsenious acid on the short-term and long-term effects of APL. Methods: 12 cases of primary or retreatment of APL, first with arsenious acid or all-trans retinoic acid induced remission, and then arsenious acid, all-trans retinoic acid and chemotherapy drugs sequential alternating treatment, sustained remission 5 a The withdrawal was observed; in the same period without arsenic acid treatment of 20 cases as a control. Results: The treatment group CR was 100%, 3 a CCR was 75%, 5 a CCR was 50%, significantly better than the control group. Conclusion: The treatment of APL can achieve a high response rate and long-term survival rate, and suggest that the treatment of APL with arsenious acid is valuable regardless of induction or remission.