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目的:观察美沙拉嗪配合中药灌肠治疗溃疡性结肠炎(UC)的疗效与不良反应。方法:选择68例轻、中度溃疡性结肠炎(UC)患者,随机分两组,两组均给予美沙拉嗪0.5g,3次/日口服;治疗组配合中药保留灌肠,1次/日,疗程均8周。根据患者治疗前、治疗结束时以及停药6个月后临床症状缓解情况,并结合结肠镜检查结果,判定疗效及复发率。结果:两组患者症状及肠镜检查结果较治疗前均有明显改善。治疗组总有效率91.6%,对照组68.8%,治疗组明显优于对照组(P<0.05);停药6个月内复发率,治疗组21.2%,对照组50.0%,治疗组明显低于对照组(P<0.05)。结论:美沙拉嗪配合中药灌肠治疗溃疡性结肠炎(UC)有较好的疗效,且疗效持久不易复发。
Objective: To observe the curative effect and adverse reactions of mesalazine combined with traditional Chinese medicine enema in the treatment of ulcerative colitis (UC). Methods: Sixty-eight patients with mild to moderate ulcerative colitis (UC) were randomly divided into two groups. Both groups were given mesalazine 0.5g orally three times a day. The treatment group received traditional Chinese medicine retention enema once a day , Treatment are 8 weeks. According to patients before treatment, the end of treatment and withdrawal of clinical symptoms 6 months after the remission, combined with colonoscopy results to determine the efficacy and recurrence rate. Results: The symptoms and colonoscopy results of both groups were significantly improved compared with those before treatment. The total effective rate was 91.6% in the treatment group and 68.8% in the control group, which was significantly better in the treatment group than in the control group (P <0.05). The relapse rate within 6 months in the treatment group was 21.2% in the treatment group and 50.0% in the control group, Control group (P <0.05). Conclusion: Mesalazine combined with traditional Chinese medicine enema treatment of ulcerative colitis (UC) has a good effect, and long lasting effect is not easy to relapse.