【摘 要】
：
I am very happy to present you with a Thematic Issue on "Drug Metabolism and Disposition in Diseases".Drug metabolism and disposition are essential to both drug
【机 构】
：
Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh Scho
论文部分内容阅读
I am very happy to present you with a Thematic Issue on "Drug Metabolism and Disposition in Diseases".Drug metabolism and disposition are essential to both drug therapy and drug safety.Besides genetic and environmental factors,it has been more and more appreciated that disease and physiological states of the patients can also impact on drug metabolism and disposition.On the other hand,the expression or activity of drug-metabolizing enzymes and transporters can have profound effect on the clinical outcome of diseases.In 2016,I edited a book of a similar title Drug Metabolism in Diseases (Academic Press/Elsevier 2016;ISBN:9780128029497) that was dedicated to disease-drug interactions.The diseases and physiological conditions covered in the 2016 Elsevier book included liver and kidney diseases,inflammation,diabetes,pregnancy,and pediatric populations.However,several other areas were left uncovered,which motivated me to edit a Thematic Issue that continues focusing on the disease-drug interactions.
其他文献
Dr. Wei Lu is a professor of School of Pharmacy at Fudan University, Shanghai, China. He received his Bachelor of pharmaceutical sciences in 2000 and Ph. D. of
医疗卫生体制改革是解决百姓“看病难”“看病贵”的根本途径,是惠及民生的重大决策。随着卫生体制改革的逐步深入,北京市属高校教职工于今年年初进入医保体系。北京高校医院
More than 50％ of marketed drugs and 90％ drug candidates are believed to be poorly water-soluble,and these figures keep growing due to input of new drug entities i
Bile acids have been traditionally viewed as detergent molecules involved in the solubilization and absorption of lipids and lipidsoluble vitamins from the inte
目的:建立荷瘤小鼠模型,观察重组人VEGF121KDR/rGEL融合毒素的抑瘤作用,为开发更加安全和有效的新型靶向抗癌药奠定基础。方法:选择人肝癌SMMC-7721细胞、食管癌KYSE-150细胞
The research for antitumor therapeutics is a timeless topic and keeps pace with times,especially chemotherapy and target therapy.Drug target identification is a
不知道你有没有注意过这样一种神秘现象，当一些飞机静止在跑道上，或者缓慢地行驶在跑道上时，发动机前有时会产生一道类似龙卷风的神秘气流。一直以来，这些神秘气流形成的原因，都被藏匿于写满无数公式的论文中，所以很多人虽然对这种现象啧啧称奇，但对其背后的原因却不是很了解。有人开玩笑说，这是发动机在“尿尿”；还有人没有认真思考，就拍脑袋说这是飞机在放油。 这些神秘气流究竟是怎么形成的呢？它们对飞机是否有危害
目的 :研究口服马兜铃酸I(AA I)在大鼠体内的药物代谢动力学特点。方法 :以12 5I标记的AA I作为示踪剂 ,给予大鼠一次口服关木通水煎剂 10g·kg-1和12 5I标记AA I(含AA I37.2
20100682 Chen Zhaoxia (Beijing Jianghe Wa-ter Conservancy and Hydropower Develop-ment Co. Ltd., Beijing 100025 , China)BJS-L50 Construction Equipment of Deep Mi
Dr.Jianxin Wang is a professor of pharmaceutics at Fudan University,School of Pharmacy.He received his Ph.D.in pharmaceutics from West China University of Medic