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克山病是地方性心肌病,由心肌病损所致原发性心肌收缩力减损是引起克山病急、慢性心力衰竭的始动病理生理基础。洋地黄用于医学实践已近二百年,至今仍被公认是一种最可靠的心脏正性收缩能药物,无疑,也是治疗克山病急、慢性心力衰竭的首选药。但洋地黄治疗量安全范围小,耐受性个体差异大,若用量不慎、用法不当、或观察不严密,常导致中毒。1973～1976年间,我室收治的94例儿童克山病心力衰竭患者中,有32例发生中毒反应(34%),其中2例因中毒死亡(6.2%)。鉴于近年来儿童克山病发病率高,几乎全部儿童病例都需短期或长期洋地黄治疗,为了总结经验,记取教训,现对儿童克山病洋地黄中毒32例进行临床分析。
Keshan disease is endemic cardiomyopathy, caused by myocardial lesion primary myocardial contractility impairment is caused by Keshan disease acute and chronic heart failure pathophysiology basis. Digitalis has been used in medical practice for nearly two hundred years and is still recognized as one of the most reliable cardiac positive systolic drugs. It is undoubtedly the drug of choice for the treatment of acute and chronic heart failure in Keshan. However, digitalis treatment of small safe range, tolerance of individual differences, if the amount of careless, improper use, or observation is not tight, often lead to poisoning. Between 1973 and 1976, 32 of the 94 K Keshan patients with heart failure admitted to my room had a toxic reaction (34%), of which 2 died of poisoning (6.2%). In view of the high incidence of Keshan disease in children in recent years, almost all cases of children need short-term or long-term digitalis treatment, in order to sum up experience and learn from the experience, children Keshan disease digitalis clinical analysis of 32 cases.