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对52例非胰岛素依赖型糖尿病(NIDDM)患者红细胞膜脂质成分和膜钠泵K~+-pNPPase(钾激活对硝基苯磷酸酶)活性进行了测定。结果显示,红细胞膜胆固醇、胆固醇/磷脂比值明显升高,膜磷脂和钠泵K~+-pNPPase活性明显降低;膜钠泵K~+-pNPPase活性降低与膜胆固醇、胆固醇/磷脂比值升高呈负相关,而与膜磷脂呈正相关。提示NIDDM患者红细胞膜脂质成分改变和膜钠泵K~+-pNPPase活性降低密切相关。
The lipid composition of erythrocyte membrane and K ~ + -pNPPase (potassium-activated para-nitrophenyl phosphatase) activity in 52 patients with non-insulin dependent diabetes mellitus (NIDDM) were measured. The results showed that the ratios of cholesterol to cholesterol / phospholipid were significantly increased and K ~ + -pNPPase activities of membrane phospholipid and sodium pump were significantly decreased. The ratio of K ~ + -pNPPase activity to membrane cholesterol and cholesterol / phospholipid increased Negatively correlated, but positively correlated with membrane phospholipids. Tip NIDDM patients erythrocyte membrane lipid composition and membrane sodium pump K ~ + -pNPPase activity is closely related.