脂类组学是一门新兴的代谢组学的分支学科,旨在系统研究生物体内所有脂类分子的特性,以及它们在蛋白质表达和基因表达调节过程中的作用。脂类参与调节生物体的众多生理过程,包括能量存储、信号转导、细胞凋亡等,随着新的分析技术的发展,特别是质谱技术的应用和发展,脂类的测定得以快速、精确和高通量地进行。大量研究表明,脂类代谢异常与肿瘤的发生发展有着密切联系,脂类组学技术的应用能揭示与肿瘤相关的脂类变化,找到其异常的代谢通路,并在肿瘤脂类生物标志物的识别、肿瘤早期诊断和抗肿瘤药物靶点的发现等方面展现出广泛的应用前景。本文就上述研究的近期进展作简要综述。 Lipidomics is an emerging branch of metabonomics that aims to systematically study the properties of all lipid molecules in organisms and their role in the regulation of protein expression and gene expression. Lipids are involved in regulating many physiological processes in organisms, including energy storage, signal transduction and apoptosis. With the development of new analytical techniques, especially the application and development of mass spectrometry, lipids are rapidly and accurately measured And high throughput. A large number of studies have shown that abnormal lipid metabolism and tumor occurrence and development are closely linked to the application of lipidomics technology can reveal tumor-related lipid changes, to find its abnormal metabolic pathways, and lipid biomarkers in the tumor Identification, early diagnosis of tumors and the discovery of anti-tumor drug targets show a wide range of applications. This article gives a brief overview of recent advances in these studies.