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目的探讨急性脑梗死患者血清超敏C反应蛋白(hs-CRP)水平的变化及其与急性脑梗死病情及预后的关系。方法对57例急性脑梗死患者(急性脑梗死组)和37例健康者(对照组)的血清hs-CRP含量进行测定,并分析其与急性脑梗死患者病情轻重及临床神经功能缺损程度评分的相关性。结果急性脑梗死组血清hs-CRP水平明显高于对照组(P<0.01),急性脑梗死不同的临床分型组间血清hs-CRP水平比较,重型组血清hs-CRP水平明显高于轻型、中型组,差异均有统计学意义(P<0.05)。脑梗死患者急性期血清hs-CRP升高水平与患者临床神经功能缺损程度呈正相关(r=0.252,P<0.05)。重型组患者神经功能学评分(NDS)的改善率低于轻型组,重型组患者治疗后死亡例数和无变化者明显多于轻型组(P<0.01)。结论血清hs-CRP水平增高与急性脑梗死发生关系密切,其水平是评价急性脑梗死严重程度和预后的一个重要的生物学指标。
Objective To investigate the changes of serum hs-CRP levels in patients with acute cerebral infarction and their relationship with the severity and prognosis of acute cerebral infarction. Methods The serum levels of hs-CRP in 57 patients with acute cerebral infarction (acute cerebral infarction group) and 37 healthy subjects (control group) were measured and compared with those of patients with acute cerebral infarction and severity of clinical neurological deficits Correlation. Results Serum levels of hs-CRP in acute cerebral infarction group were significantly higher than those in control group (P <0.01). Serum hs-CRP levels were significantly higher in severe group than in mild type, Medium group, the differences were statistically significant (P <0.05). The level of serum hs-CRP in patients with acute cerebral infarction was positively correlated with the degree of clinical neurological deficits (r = 0.252, P <0.05). The improvement rate of NDS in the severe group was lower than that in the light group. The death number and no change in the severe group were significantly higher than those in the light group (P <0.01). Conclusion The increase of serum hs-CRP is closely related to the occurrence of acute cerebral infarction. The level of serum hs-CRP is an important biological index to evaluate the severity and prognosis of acute cerebral infarction.