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为观察促性腺激素释放激素类似物 (GnRH_A)治疗儿童性早熟的疗效 ,以GnRH_A每次100μg/kg,每28d应用1次 ,对10例真性性早熟患儿进行治疗。治疗3个月后所有患儿第二性征明显退缩 ;治疗6个月后所有患儿性激素水平下降 ,BA/CA下降 ,预测成年身高[按骨龄预测成年身高 (Bayley_pinneau法 )]由治疗前 (156.4±6.2)cm升至(159.4±7.4)cm(P<0.01)。治疗过程中无明显不良反应。GnRH_A能抑制下丘脑 -垂体 -性腺轴的活动 ,使性激素分泌减少 ,从而使真性性早熟患儿第二性征逐渐退缩 ,骨龄生长减慢 ,改善最终身高 ,而且GnRH_A临床使用安全。
To observe the therapeutic effect of GnRH_A on precocious puberty in children, 10 cases of patients with precocious puberty were treated with 100 μg / kg GnRH_A every 28 days. After 3 months of treatment, the secondary sexual characteristics of all children were significantly reduced; 6 months after treatment, all children with sex hormone levels decreased, BA / CA decreased, predicted adult height [by bone age prediction adult height (Bayley_pinneau method] 156.4 ± 6.2) cm to (159.4 ± 7.4) cm (P <0.01). No obvious adverse reactions in the course of treatment. GnRH_A can inhibit the activity of the hypothalamus - pituitary - gonad axis, reducing the secretion of sex hormones, so that the second sexual characteristics of children with true precocious puberty gradually retarded, bone age growth slowed to improve the final height, and GnRH_A clinical safe use.