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川崎病(KD)后患者常出现系统性动脉硬度增加。最近报道了一些儿童川崎病后甘露糖结合植物凝血素(MBL)基因突变及儿童冠脉并发症与成人动脉粥样硬化的联系。作者分析了MBL基因型调节儿童川崎病后动脉硬度这一假说。研究了71例KD患者(42例有冠脉瘤,29例无),年龄为9.5±3.7岁,设41例年龄匹配者
Patients with Kawasaki disease often develop systemic arterial stiffness. Recently, some childhood Kawasaki disease mannose-binding lectin (MBL) gene mutations and childhood coronary complications and adult atherosclerosis. The authors analyzed the hypothesis that MBL genotypes regulate arterial stiffness after Kawasaki disease in children. 71 patients with KD (42 with coronary aneurysm, 29 without) were studied, aged 9.5 ± 3.7 years and 41 age-matched