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肾病综合征(NS)患者(尤在微小变化性肾病综合征MCNS)常伴一系列免疫学异常,如血清IgG 降低、IgM 及IgE 增高、产生循环免疫复合物、Ts 细胞活化,有报道病人血清对淋巴细胞增殖有抑制作用以及杀伤细胞介导免疫活性等。T 细胞对有丝分裂原—特异抗原或自源性非T 细胞的应答,包括一系列细胞和淋巴因子介导变化,为研究肾病综合征的细胞介导免疫作用,作者评价了NS 患者经自源性非T 细胞刺激后,T 淋巴细胞生成IL-2及对IL-2应答能力。
Nephrotic syndrome (NS) patients (especially in patients with minimal change nephrotic syndrome MCNS) often accompanied by a series of immunological abnormalities, such as serum IgG decreased, IgM and IgE increased, resulting in circulating immune complexes, Ts cell activation, there are reports of patient serum Inhibit the proliferation of lymphocytes and kill cell-mediated immune activity. T cells response to mitogen-specific antigens or self-derived non-T cells, including a series of cellular and lymphokine-mediated changes. To study the cell-mediated immunity of nephrotic syndrome, we evaluated the effects of autologous After non-T cell stimulation, T lymphocytes produce IL-2 and respond to IL-2.