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目的探讨急性敌敌畏中毒合并急性乙醇中毒患者心肌酶学及心电图变化,了解混合中毒时心肌损害情况。方法将108例急性重度敌敌畏中毒患者分为单纯敌敌畏中毒组(48例)、敌敌畏中毒合并乙醇中毒组(60例),入院后24h内抽取空腹静脉血测定肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)、α-羟丁酸脱氢酶(HBDH)、天冬氨酸氨基转移酶(AST),并常规描记体表心电图。结果急性敌敌畏中毒合并急性乙醇中毒患者心肌酶明显高于单纯敌敌畏中毒组(P<0.01);混合中毒组室性早搏、室性心动过速发生率高于单纯中毒组。结论与单纯敌敌畏中毒相比,急性敌敌畏中毒合并急性乙醇中毒患者心肌损害重,更易导致恶性心律失常的发生。
Objective To investigate the changes of myocardial enzymes and electrocardiogram (ECG) in patients with acute dichlorvos poisoning complicated with acute alcoholism and to understand the myocardial damage caused by mixed poisoning. Methods A total of 108 patients with acute severe dichlorvos poisoning were divided into simple dichlorvos poisoning group (48 cases) and dichlorvos poisoning group (60 cases). After 24h of admission, fasting venous blood samples were taken for determination of creatine kinase (CK), creatine kinase CK-MB, LDH, HBDH, AST, and routinely labeled epicardiogram. Results Myocardial enzymes in patients with acute dichlorvos poisoning complicated with acute alcoholism were significantly higher than those in pure dichlorvos poisoning group (P <0.01). The incidence of ventricular premature beats and ventricular tachycardia in mixed poisoning group was higher than that in simple poisoning group. Conclusion Compared with pure dichlorvos poisoning, acute dichlorvos poisoning complicated by acute alcoholism in patients with myocardial damage, more likely to lead to the occurrence of malignant arrhythmia.