氯氮平自临床应用不久因出现粒细胞缺乏症(简称粒缺)使其推广严格受限。其后的临床试验表明氯氮平对传统的抗精神病药无效或不耐受这类药物治疗的精神分裂症患者疗效较好,且定期检查病人的白血球可早期发现粒细 Clozapine shortly after its clinical application due to the emergence of agranulocytosis (referred to as the lack of grain) to promote its strictly limited. Subsequent clinical trials show that clozapine is not effective or resistant to conventional antipsychotic drugs in patients with schizophrenia treatment is better, and regular examination of patients with white blood cells can be early detection of fine