AIM:To investigate the association between Ser326Cys human oxoguanine glycosylase 1(hOGG1) polymorphism and atrophic gastritis and gastric cancer after Helicobacter pylori(H.pylori) eradication.METHODS:A total of 488 subjects(73 patients with gastric cancer,160 with atrophic gastritis after H.pylori eradication and 255 controls) were prospectively collected.Polymerase chain reaction-restriction fragment length polymorphism analysis was performed to distinguish hOGG1 Ser326Cys polymorphism.Statistical analysis was conducted by two-sample t test for continuous variables and χ2 test for categorical variables.Logistic regression models were used to f ind the risk factors for gastric cancer and atrophic gastritis.RESULTS:Neither the hOGG1 Ser/Cys nor the Cys/Cys genotype was associated with gastric cancer.Compared with the Ser/Ser genotype,odds ratio(OR) for Ser/Cys was 0.96,(95% CI:0.51-1.84) and OR for Cys/Cys was 1.1(95% CI:0.48-2.1).No association was detected between hOGG1 polymorphism and Lauren type of gastric cancer(P=0.61) either.However,Ser/Cys and Cys/Cys were signif icantly associated with atrophic gastritis with OR:1.76 for Ser/Cys(95% CI:1.03-3.0) and 2.38 for Cys/Cys(95% CI:1.34-4.23).After controlling for age,gender,smoking and alcohol,there were still signif icant associations with OR:2.05 for Ser/Cys(95% CI:1.14-3.68) and 2.76 for Cys/Cys(95% CI:1.47-5.18).CONCLUSION:HOGG1 polymorphisms(Cys/Cys and Ser/Cys) are associated with atrophic gastritis.No significant association is detected between hOGG1 polymorphisms(Cys/Cys or Ser/Cys) and gastric cancer. AIM: To investigate the association between Ser326Cys human oxoguanine glycosylase 1 (hOGG1) polymorphism and atrophic gastritis and gastric cancer after Helicobacter pylori (H. pylori) eradication. METHODS: A total of 488 subjects (73 patients with gastric cancer, 160 with atrophic gastritis after H. pylori eradication and 255 controls) were prospectively collected. Polymerase chain reaction-restriction fragment length polymorphism analysis was performed to distinguish hOGG1 Ser326Cys polymorphism. Statistical analysis was conducted by two-sample t test for continuous variables and χ2 test for categorical variables. Logistic regression models were used to f ind the risk factors for gastric cancer and atrophic gastritis .RESULTS: Neither the hOGG1 Ser / Cys nor the Cys / Cys genotype was associated with gastric cancer. Compared with the Ser / Ser genotype, odds ratio ) for Ser / Cys was 0.96 (95% CI: 0.51-1.84) and OR for Cys / Cys was 1.1 (95% CI: 0.48-2.1) .No association was detected between hOGG1 polymorphis Serum levels of Ser / Cys and Cys / Cys were signif icantly associated with atrophic gastritis with OR: 1.76 for Ser / Cys (95% CI: 1.03-3.0) and 2.38 for After controlling for age, gender, smoking and alcohol, there were still signif icant associations with OR: 2.05 for Ser / Cys (95% CI: 1.14-3.68) and 2.76 for CYS / Cys (95% CI: 1.47-5.18) .CONCLUSION: HOGG1 polymorphisms (Cys / Cys and Ser / Cys) are associated with atrophic gastritis. No significant association is detected between hOGG1 polymorphisms (Cys / Cys or Ser / Cys) and gastric cancer.