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目的:探讨聚甲酚磺醛联合复方沙棘籽油栓治疗宫颈上皮内瘤变(CIN)的临床效果。方法:对102例CINⅠ患者使用聚甲酚磺醛联合复方沙棘籽油栓阴道给药治疗(治疗组),另选取82例CINⅠ患者使用先理盐水联合复方沙棘籽油栓治疗(对照组),治疗6个月后观察两组患者宫颈及宫颈CIN级别的变化,根据结果进行疗效分析。结果:治疗组治疗6个月后患者宫颈糜烂范围好转65例,好转率为63.7%;对照组好转35例,好转率为42.7%,两组差异有统计学意义(P<0.05)。治疗组CINⅠ的逆转率为65.7%。结论:聚甲酚磺醛联合复方沙棘籽油栓治疗宫颈低级别病变(CINⅠ)疗效良好,值得推荐使用。
Objective: To investigate the clinical effect of polyoxymethol sulfonate and compound seabuckthorn seed oil suppository in the treatment of cervical intraepithelial neoplasia (CIN). Methods: A total of 102 patients with CIN Ⅰ were treated with polyresin sulphonic acid and compound seabuckthorn seed oil in the vaginal administration group (treatment group). Another 82 patients with CIN Ⅰ were treated with propofol saline and compound seabuckthorn seed oil suppositories (control group) After 6 months of treatment, the changes of cervical and cervical CIN level in both groups were observed, and the curative effect was analyzed according to the results. Results: Six months after the treatment, the improvement rate of cervical erosion ranged from 65.7% in the treatment group to 63.7% in the control group, and 35 cases improved in the control group (42.7%). There was significant difference between the two groups (P <0.05). The reversal rate of CIN Ⅰ in the treatment group was 65.7%. CONCLUSION: The combination of polycresol sulfonate and compound seabuckthorn seed oil suppository for the treatment of low grade cervical lesions (CIN Ⅰ) has a good curative effect and is recommended.