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给予未节制饮食的10～18周龄DBM小鼠口服降糖片200mg/kg,此剂量对正常小鼠无作用,4小时引起血糖下降42%(P<0.001)。低血糖作用在2小时即明显出现(-33%),一直持续降至6小时(-37%,P<0.001)。任何时候都未同时表现出血液乳酸增加。血浆免疫反应的胰岛素(IRI)在2小时为466.5±240μU/ml,与开始时的546±199μU/ml对比没有变化。但于4小时时减低至415±242μU/ml(P<0.05),于6小时时减低更明显为216±160μU/ml(P<0.001)。给予400mg/kg时,则于第4小时血糖下降52%,IRI减少50%,血乳酸
DBM mice 10 to 18 weeks of age who were given uncontrolled diet were given 200 mg / kg oral glucose-lowering tablets, which showed no effect on normal mice and a 42% decrease in blood glucose after 4 hours (P <0.001). Hypoglycaemic effects were evident at 2 hours (-33%) and continued to decrease to 6 hours (-37%, P <0.001). No increase in blood lactate was demonstrated at all times. Plasma immune response insulin (IRI) was 466.5 ± 240 μU / ml at 2 hours, unchanged from the initial 546 ± 199 μU / ml. But decreased to 415 ± 242 μU / ml (P <0.05) at 4 hours and decreased more significantly to 216 ± 160 μU / ml at 6 hours (P <0.001). Given 400mg / kg, then in the first 4 hours of blood sugar decreased 52%, IRI reduced by 50%, blood lactate