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利用非水相酶促酯化反应 ,对 β-阻断剂类药物普萘洛尔的手性中间体 (± ) - 1-氯 - 3-(1-萘氧 ) - 2 -丙醇进行了拆分研究 ,考察了酰化剂、溶剂的影响 ,同时对几种脂肪酶的催化活性和选择性进行了比较。
The chiral intermediate (±) - 1-chloro-3- (1-naphthalenyloxy) -2-propanol, a β-blocker drug propranolol, was subjected to a non-aqueous enzymatic esterification The separation studies investigated the effect of acylating agents and solvents, and compared the catalytic activities and selectivities of several lipases.