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全球有超过3.5亿慢性乙型肝炎患者,尽管接种预防性乙型肝炎病毒(hepatitis B vaccine,HBV)疫苗近30年,HBV感染依然是全世界严重的公共卫生问题,慢性乙型肝炎患者将面临着发展成肝硬化甚或肝癌的高风险。HBV是小包膜DNA病毒,通过RNA中间体进行复制。核衣壳内的病毒基因组DNA由3.2 kb局部开环双链DNA(rcDNA)组成,入核后形成共价闭合环DNA(cccDNA)。当前的抗病毒方式可以清除HBV病毒颗粒及其颗粒成分,但不能清除存
There are more than 350 million people with chronic hepatitis B in the world. Despite nearly 30 years of vaccination against the hepatitis B vaccine (HBV), HBV infection remains a serious public health problem in the world and patients with chronic hepatitis B will face The risk of developing cirrhosis or even liver cancer is high. HBV is a small envelope DNA virus that replicates through RNA intermediates. The viral genomic DNA in the nucleocapsid consists of 3.2 kb of partially open-loop double-stranded DNA (rcDNA) that forms a covalently closed loop DNA (cccDNA) upon entry into the nucleus. The current antiviral approach can clear the HBV virus particles and their particulate components, but can not be cleared