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目的：探讨绝经前和绝经后患者应用激素替代治疗（HRT）和植物雌激素（PE）治疗对围绝经期综合征的疗效，以期提高围绝经期患者生活质量．方法：采用前瞻性研究，绝经前患者102例，绝经后患者76例．其中HRT组106例、PE组72例．观察患者在用药前、用药3 mo后的围绝经期症状及血脂变化，并观察两种治疗方法的副作用．结果：两组患者的围绝经期症状均有明显减轻，但PE的作用明显次于HRT （P＜0．05）；HRT组中患者血脂中低密度脂蛋白较用药前明显下降（P＜0．05），高密度脂蛋白较用药前明显升高（P＜0．05）；而PE组中患者血脂波谱无明显改变；治疗过程中所引起的副作用HRT组明显高于PE组（P＜0．05）．结论：HRT和PE均能明显减轻患者的围绝经期症状，HRT能改善血脂波谱状态，而PE能减少患者因服药带来的副作用．“,”AIM:To compare the treatment ef ects of hormone replacement therapy (HRT)and phytoestrogen (PE)for perimenopausal women.METHODS:Total y 178 patients (102 premenopausal and 76 postmenopausal women)were randomely divided into 2 groups:106 were given HRT and 76 were given PE for 3 months.The side ef ects were compared between the 2 therapies.RESULTS:After 3 months of treatment,perimenopausal symptoms of al patients in the 2 groups were improved,but the improvement in PE group was less obvious than that in HRT group (P<0.05).Lowdensity lipoprotein decreased and highdensity lipoprotein increased in HRT group after treatment (P<0.05 vs PE group);www.zhlzw.com there was no any significant changesinlipoproteinsinPEgroup.SideefectinHRTwasmoresignificantlyseriousthanthatofPEtherapy(P<0.05).CONCLUSION:HRTandPEcanal significantlyimproveperimeno-pausal symptoms,but HRT is bet er in lipoprotein improvement,and PE caused side ef ect is less.