肿瘤的生长、侵袭、转移、复发和预后均与肿瘤血管生成有关,肿瘤微环境在炎症及炎症介质的刺激下,通过多种机制促进肿瘤血管生成。肿瘤侵袭和转移的复杂机制在于肿瘤细胞与各种宿主细胞之间发生广泛作用,其中肿瘤与血管内皮之间的相互作用在支持肿瘤血行转移中扮演了重要角色。就肿瘤血管生成机制以及信号调控的研究进展作一综述。 Tumor growth, invasion, metastasis, recurrence and prognosis are related to tumor angiogenesis, tumor microenvironment in inflammation and inflammatory mediators stimulated by a variety of mechanisms to promote tumor angiogenesis. The complex mechanism of tumor invasion and metastasis lies in the extensive role that tumor cells play with various host cells, where the interaction between the tumor and the vascular endothelium plays an important role in supporting the metastasis of the tumor blood. The progress of tumor angiogenesis and signal regulation are reviewed.