自从先天性无胸腺裸小鼠(简称裸小鼠)问世20多年来,尤其是在Rygaard和Povlsen首先成功地移植人类恶性肿瘤到裸小鼠后,这种免疫缺陷动物已广泛应用于免疫学和肿瘤等疾病的研究。在皮肤病方面,以裸小鼠进行皮肤肿瘤、皮肤真菌病等有关研究,国外报道较多。国内至今报道甚少,因此,为向国内皮肤病学者推荐对免疫缺陷型动物特别是裸小鼠扩大利用,本文特此进行简略综述。 Since the advent of congenital athymic nude mice (referred to as nude mice) more than 20 years ago, especially after Rygaard and Povlsen first successfully transplanted human malignancies to nude mice, the immunodeficient animals have been widely used in immunology and Cancer and other diseases. In skin diseases, nude mice for skin tumors, skin fungal diseases and other related studies, more foreign reports. So far, few reports have been reported in China. Therefore, in order to recommend to domestic dermatologists expanded use of immunodeficient animals, especially nude mice, this article is briefly reviewed.