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目的探讨肥胖者颈动脉内膜中层厚度(IMT)同血铁蛋白(SF)、Apelin及HOMA-IR的关系。方法根据颈动脉IMT将肥胖者80例分为IMT增厚组(A组)和IMT正常组(B组),并选择80名健康者(C组)进行比较,分别进行SF、Apelin及HOMA-IR等参数测定。结果 A组的颈动脉IMT、SF、Apelin和HOMA-IR均分别显著高于B组和C组,颈动脉IMT和SF、Apelin、HOMA-IR等呈正相关,SF水平与SBP、FPG、HOMA-IR等呈显著正相关,Apelin水平与HOMA-IR、FIns、BMI等呈显著正相关。结论部分肥胖者颈动脉IMT已明显升高,而血SF和Apelin可能对预测肥胖者早期动脉粥样硬化有重要意义。
Objective To investigate the relationship between carotid intima-media thickness (IMT) and serum ferritin (SF), Apelin and HOMA-IR in obese subjects. Methods Eighty obese patients were divided into IMT thickening group (group A) and IMT normal group (group B) according to carotid artery IMT. 80 healthy subjects (group C) were selected for comparison. SF, Apelin and HOMA- IR and other parameters measured. Results The IMT, SF, Apelin and HOMA-IR of carotid arteries in group A were significantly higher than those in group B and C, respectively. There was a positive correlation between carotid IMT, SF, Apelin and HOMA- IR, etc. There was a significant positive correlation between Apelin levels and HOMA-IR, FIns, BMI and other significant positive correlation. Conclusion The carotid IMT of some obese patients has been significantly increased, while the serum levels of SF and Apelin may play an important role in the prediction of early atherosclerosis in obese subjects.