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通过热开环聚合方法,合成了聚二氯膦腈,再利用亲核取代反应合成了含导电基团苯胺四聚体的聚膦腈。采用核磁共振、红外、紫外可见光谱、循环伏安法等对聚合物的结构和性能进行了表征;体外细胞实验采用RSC96永生化雪旺细胞测试材料的生物相容性。结果表明,聚合物的分子量为-Mw=2.1×105,-Mn=6.2×104,分子量分布d=-Mw/-Mn=3.38;聚合物具有优良的成膜性能和溶解性能;经质子酸掺杂后的聚合物具有一定的电活性;材料与RSC96细胞生物相容性良好,能够显著地促进细胞的分化和增殖。这种新型材料的合成方法为生物医用材料的合成提供了一条新途径。
Poly (dichlorophosphazene) was synthesized by thermal ring-opening polymerization and polyphosphazene containing aniline tetramer as conductive group was synthesized by nucleophilic substitution reaction. The structure and properties of the polymers were characterized by 1H NMR, IR, UV-visible spectra and cyclic voltammetry. The in vitro experiments were performed on biocompatible materials using RSC96 immortalized Schwann cells. The results showed that the molecular weight of the polymer was -Mw = 2.1 × 105, -Mn = 6.2 × 104, and the molecular weight distribution was d = -Mw / -Mn = 3.38. The polymer had excellent film-forming and dissolution properties. Heterozygous polymers have some electrical activity; the material has good biocompatibility with RSC96 cells, which can significantly promote cell differentiation and proliferation. The synthesis of this new material provides a new avenue for the synthesis of biomedical materials.