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许多心绞痛病人单用β阻滞剂不能完全控制症状时常用几类药物,加用钙通道阻滞剂和/或硝酸酯是否优于单用β阻滞剂,目前还不清楚。 18例用阿替洛尔(A)治疗稳定型心绞痛的病人完成了双盲、随机和交叉试验。A(100mg/d)分别加安慰剂、单硝酸异山梨醇(M,40mg/d)或硝苯啶(N,40mg/d),或者三种药(A+N+M)合用。每治疗4周末作平板运动试验及24小时动态心电图以评价疗效。
It is unclear at this time that many types of angina patients who use beta blockers alone may not be able to fully control their symptoms. It is unclear whether the addition of calcium channel blockers and / or nitrates will be superior to beta blockers alone. Eighteen patients treated with atenolol (A) for stable angina achieved a double-blind, randomized, and crossover trial. A (100mg / d) plus placebo, isosorbide mononitrate (M, 40mg / d) or nifedipine (N, 40mg / d), or three drugs (A + N + M) combined. Every treatment for 4 weeks for the treadmill exercise test and 24-hour Holter in order to evaluate the efficacy.