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目的：观察中药复方柴蔻冲剂对大鼠慢性酒精性肝损伤的防护作用。方法：来用高浓度酒精每ｄ分次 灌胃，同时酒精饮料饲养制备大鼠慢性酒精肝损伤模型，应用光镜和电镜观察大鼠肝脏组织学变化及超微结 构，检测血清ＡＬＴ、ＡＳＴ、ＧＣＴ活性。观察不同剂量柴蔻冲剂对酒精中毒性肝损伤的保护作用。结果：酒精损伤 组肝功能有严重损伤，所有大鼠均出现了脂肪肝，９０％的动物发生了酒精性肝炎，部分大鼠（２２％）可见肝间质 反应性增生，柴蔻冲剂预防组肝功能、肝组织学及超微结构损伤显著减轻，优于丙基硫氧嘧啶对照组。结论：柴 蔻冲剂对酒精性肝损伤具有良好的防护作用。
OBJECTIVE: To observe the protective effect of traditional Chinese compound Chaigu Granules on chronic alcoholic liver injury in rats. METHODS: Rats were fed with high-alcohol alcohol every d, and alcoholic drinks were fed to prepare chronic alcoholic liver injury model. The histological changes and ultrastructure of rat liver were observed by light and electron microscopy. Serum ALT, AST, GCT activity. Observe the protective effects of different doses of Chaixi powder on alcohol-induced liver injury. Results: Liver function was severely damaged in the alcohol-injured group. Fatty liver appeared in all rats, alcoholic hepatitis occurred in 90% of the animals, and interstitial reactive hyperplasia was seen in some rats (22%). Liver function, hepatic histology and ultrastructural injury were significantly reduced and superior to propylthiouracil control group. Conclusion: Chaiqi Granule has good protective effect on alcoholic liver injury.