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目的探讨低分子肝素钠对过敏性紫癜性肾炎(HSPN)肾损害的预防效果。方法过敏性紫癜(HSP)患儿62例,病程在30d以内。随机分为治疗组(32例)和对照组(30例)。两组均给予常规治疗。治疗组加用低分子肝素钠100IU/kg,1次/d静脉滴注,连用7d。平均随访6个月。结果治疗组HSPN发生率6.3%(2/32),明显低于对照组的33.3%(10/30)(P<0.05)。治疗组HSPN肾损害程度较对照组轻,且出现时间较晚(P<0.05)。治疗组行低分子肝素钠治疗过程中未出现过敏、注射部位皮肤坏死、血小板减少、动脉或静脉血栓等不良反应。结论低分子肝素钠对HSPN有预防作用。
Objective To investigate the preventive effect of low molecular weight heparin on renal damage in children with Henoch-Schonlein purpura nephritis (HSPN). Methods 62 cases of children with Henoch-Schonlein Purpura (HSP), the course of which was within 30 days. Randomly divided into treatment group (32 cases) and control group (30 cases). Both groups were given routine treatment. The treatment group plus low molecular weight heparin 100IU / kg, 1 / d intravenous infusion, once every 7d. The average follow-up of 6 months. Results The incidence of HSPN in the treatment group was 6.3% (2/32), which was significantly lower than that in the control group (33.3%, 10/30) (P <0.05). The HSPN nephropathy in the treatment group was lighter than that in the control group, and appeared more late (P <0.05). Low molecular weight heparin treatment group treated with no allergies, injection site dermal necrosis, thrombocytopenia, arterial or venous thrombosis and other adverse reactions. Conclusion Low molecular weight heparin can prevent HSPN.