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目的探讨孕中期唐氏筛查在产前诊断中的价值。方法应用时间分辨荧光免疫法对2012年6月至12月做产前检查的1679例孕中期(14～20+6周)孕妇进行血清标记物三联方案(AFP+free-β-HCG+uE3)检测。应用唐氏综合征风险计算软件,以1/250为高危切割值。知情同意,自愿选择行产前诊断,于孕18～24周左右在超声引导下进行羊膜腔穿刺,抽取羊水培养进行胎儿染色体核型分析。结果唐氏筛查高风险组唐氏综合征发生率(2.75%)明显高于低风险组(0.13%),差异有统计学意义(P<0.01)。结论孕中期唐氏筛查风险值可作为侵入性产前诊断的重要参考指标。
Objective To investigate the value of Down’s screening during prenatal diagnosis in prenatal diagnosis. Methods A total of 1679 pregnant women with gestational age from 14 to 20 + 6 weeks who underwent prenatal examination between June 2012 and December 2012 were enrolled in this study. AFP + free-β-HCG + uE3 Detection. Apply Down’s syndrome risk calculation software to 1/250 for high-risk cutting values. Informed consent, voluntarily choose prenatal diagnosis, in pregnancy about 18 to 24 weeks under the guidance of ultrasound amniocentesis, extraction of amniotic fluid culture fetal karyotype analysis. Results The incidence of Down’s syndrome (2.75%) in Down’s screening high-risk group was significantly higher than that in low-risk group (0.13%), the difference was statistically significant (P <0.01). Conclusion The risk of Down’s screening during pregnancy may serve as an important reference for invasive prenatal diagnosis.