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当今国内外应用徼核技术研究遗传疾病,恶性肿瘤已有不少报道。对肝炎、肝硬化是否作为肝癌的癌前病变尚有不同的观点,一般认为患乙型肝炎、肝硬化的病人容易发生肝癌,特别是HBsAg阳性者。因此,我们进一步研究肝癌、肝硬化和乙型肝炎病人外周淋巴细胞胞浆中微核出现的规律,以便探讨机体的恶变状况和癌变机理。我们选取经门诊确诊的和刚入院的HBsAg阳性、未经任何治疗的肝癌、肝硬化和乙型肝炎病人各50例,同时取50例健康供血员作对照。
At present, the application of nuclear technology at home and abroad to study genetic diseases, cancer has been a lot of reports. For hepatitis, cirrhosis of liver cancer as a precancerous lesion there are different points of view, generally believed that suffering from hepatitis B, liver cirrhosis patients prone to liver cancer, especially HBsAg-positive. Therefore, we further study the regularity of micronuclei in the cytoplasm of peripheral lymphocytes of patients with hepatocellular carcinoma, cirrhosis and hepatitis B in order to explore the malignant transformation and carcinogenesis mechanism. We selected outpatient diagnosed and admitted to hospital HBsAg positive, without any treatment of liver cancer, cirrhosis and hepatitis B patients 50 cases, taking 50 healthy blood donors as a control.