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Ranitidine是一种新的、不含咪唑环的组织胺H_2-受体拮抗剂。在健康志愿者,Ranitidne静脉注射或经胃、十二指肠给药,抑制五肽胃泌素刺激的胃酸分泌较甲氰咪胍强4～5倍。对十二指肠溃疡患者,Ranitidine亦显著抑制五肽胃泌素、组织胺与试餐刺激的胃酸分泌,也抑制24小时胃酸与夜间胃酸分泌;多数患者的Ranitidine IC50低于甲氰咪胍7倍。因此从理论而言,Ranitidine可能是治疗十二指肠溃疡很
Ranitidine is a novel imidazole ring-free histamine H 2 -receptor antagonist. In healthy volunteers, intravenous injection of Ranitidne or by the stomach, duodenum, inhibition of pentagastrin-stimulated gastric acid secretion stronger than cimetidine 4 to 5 times. For patients with duodenal ulcer, Ranitidine also significantly inhibited pentagastrin, histamine and test-meal-stimulated gastric acid secretion, but also inhibited 24-hour gastric acid and nighttime gastric acid secretion; Ranitidine IC50 in most patients was lower than that of cimetidine 7 Times So theoretically, Ranitidine may be a cure for duodenal ulcers