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目的 对足月妊娠发生胎膜早破的产妇予口服米索前列醇 (米索 )与静滴催产素引产的效果进行比较研究。方法 选择 10 0例尚未临产的胎膜早破初产妇 ,随机分为米索组和催产素组。米索组予米索 5 0μg口服 ,若有效宫缩尚未发动 ,6小时后重复给药一次。催产素按常规使用方法静滴。结果 米索组与催产素组引产成功率分别为 6 7.3%、 6 4.5 % ,从引产至阴道分娩时间分别为 (12 .2 2± 3.5 1) h、 (18.10± 3.2 4) h,米索组有 2例需加用催产素。分娩方式、新生儿 Apgar评分两组比较 ,差异均无显著性 (P >0 .0 5 ) ,但宫缩过强及胎粪污染的发生率米索组较高。结论 口服米索可替代催产素静滴用于胎膜早破初产妇的引产
Objective To compare the effect of oral administration of misoprostol (misoprostol) and intravenous oxytocin on maternal premature rupture of membranes in full-term pregnancy. Methods One hundred and ten primiparous women with premature rupture of membranes were selected and randomly divided into misoprostol and oxytocin groups. Misoprostol misoprostol 50μg orally, if the effective contractions have not yet started, once 6 hours after repeated administration. Oxytocin intravenously by conventional methods. Results The successful rates of induction of labor in misoprostol and oxytocin groups were respectively 6 7.3% and 6 4.5%, and the time from induction to vaginal delivery were (12.22 ± 3.51) h and (18.10 ± 3.2 4) h respectively, Group 2 patients need to add oxytocin. Mode of delivery, Apgar score of neonates showed no significant difference (P> 0.05), but the incidence of uterine contractions and meconium contamination was higher in misoprostol group. Conclusion Oral administration of misoprostol can replace oxytocin intravenous infusion for premature rupture of membranes