目的：测定中药陈皮中川陈皮素的含量。方法：采用ＲＰＨＰＬＣ法，色谱条件为μＢｏｎｄａｐａｋＣ１８柱，四氢呋喃乙腈甲醇水（１５∶５∶２２∶５８）为流动相，检测波长３２８ｎｍ。结果：不同批号陈皮药材中川陈皮素的含量为０．０５１％～０．５０９％，平均加样回收率为９９．２％，ＲＳＤ为１．９％。结论：该含量测定方法的建立为控制陈皮药材的质量标准提供了依据。 Objective: To determine the content of nobiletin in Chinese dried tangerine peel. Methods: RP-HPLC method, the chromatographic conditions μ  BondapakC18 column, tetrahydrofuran  acetonitrile  methanol  water (15:5:22:58) as the mobile phase, the detection wavelength of 328nm. Results: The contents of nobiletin in different lotus cultivars ranged from 0.051% to 0.509% with the average recovery of 99.2% and the RSD of 1.9%. Conclusion: The determination of content of this method provides a basis for quality control of dried tangerine peel.