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目的:探讨直肠癌细胞凋亡及c-erbB-2癌基因表达与直肠癌预后的关系。方法:应用免疫组化TUNEL及SP法对106例直肠癌进行细胞凋亡及c-erbB-2癌基因表达检测,并分别以已知阳性对照切片作为阳性对照。结果:不同分化程度直肠癌中,细胞凋亡及c-erbB-2的阳性率不同。分化程度高,则细胞凋亡率高;分化程度低,则c-erbB-2阳性率高。同时有细胞凋亡和c-erbB-2阳性表达的几率在低分化直肠癌中最高。结论:细胞凋亡及c-erbB-2可作为判定直肠癌预后的可靠指标。
Objective: To investigate the relationship between the apoptosis of rectal cancer cells and the expression of c-erbB-2 oncogene and the prognosis of rectal cancer. Methods: TUNEL and SP methods were used to detect the expression of c-erbB-2 oncogene in 106 cases of rectal cancer. The positive control cells were used as positive control. Results: The positive rate of apoptosis and c-erbB-2 in different differentiation degree rectal cancer were different. High degree of differentiation, the high rate of apoptosis; low differentiation, the positive rate of c-erbB-2. At the same time, the probability of apoptosis and positive expression of c-erbB-2 was the highest in poorly differentiated rectal cancer. Conclusion: Apoptosis and c-erbB-2 can be used as a reliable indicator of the prognosis of rectal cancer.