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We herein report the case of a 46 year old man with chronic inflammatory demye linating polyneuropathy (CIDP)-with hyperIgEaemia. The patient presented with b ilateral weakness, generalized hyporeflexia, and mild paresthesia of the fingers of both hands. Nerve conduction studies revealed multiple sites of motor conduc tion block inthe absence of sensory abnormalities. Muscle strength increased, as did compound muscle action potential (CMAP)-amplitude immediately after the in travenous infusion of immunoglobulin (IVIg). Serum IgE levels also fluctuated in parallel with his relapsing-remitting clinical course. We propose that pure mo tor CIDP may be immune mediated and suggest that IgE-mediated allergy may be on e potential cause of this condition.
The patient presented with bIlateral weakness, generalized hyporeflexia, and mild paresthesia of the fingers of both hands. Nerve conduction studies demonstrated multiple sites of motor conduction block inthe absence of sensory abnormalities. Muscle strength increased, as did compound muscle action potential (CMAP) -amplitude immediately after the in travenous infusion of immunoglobulin (IVIg). Serum IgE levels also fluctuated in parallel with his relapsing- remitting clinical course. We propose that pure mo tor CIDP may be immune mediated and suggest that IgE-mediated allergy may be on e potential cause of this condition.