论文部分内容阅读
人酸性磷酸酶是多分子形式,由不同染色体上的多个非等位基因编码生成。红细胞酸性磷酸酶已用作为研究群体遗传的标志,溶酶体的酸性磷酸酶也是特征酶,而人的前列腺酸性磷酸酶是诊断前列腺转移癌的有用指标。前列腺酸性磷酸酶(PAP)同溶酶体酸性磷酸酶(LAP)在分子大小和动态性质上相似,然而其结构和功能是有差异的,具有抗原特异性。作者试图制备单克隆抗体作为一种探针来研究PAP的抗原决定簇,以期能对人酸性磷酸酶的生
Human acid phosphatase is a multi-molecular form that is encoded by multiple non-alleles on different chromosomes. Erythrocyte acid phosphatase has been used as a marker of population genetic research, lysosomal acid phosphatase is also a characteristic enzyme, and human prostate acid phosphatase is a useful indicator of prostate cancer metastasis. Prostate acid phosphatase (PAP) is similar in molecular size and dynamic character to lysosomal acid phosphatase (LAP), but its structure and function are different and antigen specific. The authors attempted to prepare monoclonal antibodies as a probe to study the antigenic determinants of PAP in the hope of being able to metabolize human acid phosphatase