糖尿病 (DM)微血管病变是导致DM病死率和病死率升高的主要原因。它们会随着病程迁延和血糖控制不良而迅速发展 ,严重影响DM患者的生活质量。近年来大量的研究表明 ,多元醇通路的激活参与了DM微血管病变的发生及发展。醛糖还原酶 (AR)是多元醇通路的限速酶 ,AR基因的多态性与DM Diabetes mellitus (DM) microangiopathy is the leading cause of DM mortality and mortality. They develop rapidly with poor disease duration and poor glycemic control, and seriously affect the quality of life of DM patients. In recent years, a large number of studies have shown that the activation of polyol pathway involved in the occurrence and development of DM microangiopathy. Aldose reductase (AR) is the rate-limiting enzyme in the polyol pathway and the AR gene polymorphism is associated with DM