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在抗疱疹病毒药中羟甲基鸟嘌呤(acyclovir,AC)是最引人注目的药物,因为其抗病毒活性显著、细胞毒性低,是一种与阿糖胞苷、疱疹净、三氟苷以及阿糖腺苷等有关的核苷酸类抗病毒药。抗病毒活性疱疹病毒对AC的敏感度由大到小依次为:单纯疱疹病毒Ⅰ型,单纯疱疹病毒Ⅱ型,水痘带状疱疹病毒,EB病毒及巨细胞病毒(CMV)。体外试验表明,AC抗单纯疱疹Ⅰ、Ⅱ型病毒的活性一般强于疱疹净、三氟苷及阿糖腺苷。使单纯疱疹病毒减毒50％的AC浓度是0.5μM,与阿糖胞苷相近。
Among herpes anti-herpes viruses, acyclovir (AC) is the most notable drug because of its significant antiviral activity and low cytotoxicity. It is a cytotoxic agent that binds cytarabine, herpes zoster, And adenosine and other related nucleotide antivirals. The sensitivity of anti-virus active herpesvirus to AC was as follows: herpes simplex virus type 1, herpes simplex virus type 2, varicella-zoster virus, Epstein-Barr virus and cytomegalovirus (CMV). In vitro tests showed that the AC anti-herpes simplex virus type Ⅰ and Ⅱ virus activity is generally stronger than herpes net, Trifluoside and vidarabine. The AC concentration that attenuated herpes simplex virus by 50% was 0.5 μM, similar to cytarabine.