HLAⅠ类分子对抗原的呈递在抗肿瘤CD8+T细胞免疫中起到重要作用。抗原呈递的完成离不开LMP和TAP。在多种恶性肿瘤中都发现了HLAⅠ类分子、LMP和TAP的异常表达,并发现与肿瘤临床特征及预后相关。已有的研究证实HLAⅠ类分子、LMP和TAP的异常表达是肿瘤免疫逃逸密机制之一,本文就HLAⅠ类分子、LMP和TAP与恶性肿瘤关系的研究进展作综述。 The presentation of antigens by HLA class I molecules plays an important role in the anti-tumor CD8 + T cell immunity. The completion of antigen presentation can not be separated from LMP and TAP. Abnormal expression of HLA class I molecules, LMP and TAP were found in many malignant tumors and found to be associated with the clinical characteristics and prognosis of the tumor. It has been proved that the abnormal expression of HLA class I molecules, LMP and TAP is one of the mechanisms of tumor immune escape. In this paper, the research progress on the relationship between HLA class I molecules, LMP, TAP and malignant tumors is reviewed.