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目的观察全自动换血法治疗新生儿高胆红素血症的效果及对机体内环境的影响。方法对56例高胆红素血症新生儿采用全自动换血疗法,观察换血前后血常规、生化及血胆红素水平的变化。结果换血后血总胆红素和间接胆红素均较换血前显著降低(P<0.01),总胆红素换出率为49.7%。换血后血钙、血白细胞、血小板明显下降(P<0.01或P<0.05),但血红蛋白、血糖较换血前明显升高(P<0.01或P<0.05),换血前后血钾、血钠及pH值比较,差异无统计学意义(P>0.05)。结论全自动换血法治疗新生儿高胆红素血症安全有效,对机体内环境有一定影响,但这些影响不对新生儿构成生命危险。
Objective To observe the effect of automatic blood transfusion on neonatal hyperbilirubinemia and its effect on the environment in vivo. Methods Fifty-six neonates with hyperbilirubinemia were treated with automatic blood exchange therapy to observe the changes of blood routine, biochemical and serum bilirubin levels before and after transfusion. Results The blood total bilirubin and indirect bilirubin were significantly lower than those before blood exchange (P <0.01), and the total bilirubin exchange rate was 49.7%. Blood transfusion, blood calcium, white blood cells, platelets decreased significantly (P <0.01 or P <0.05), but hemoglobin, blood glucose was significantly higher than before the exchange (P <0.01 or P <0.05), before and after the exchange of blood potassium, sodium and pH The difference was not statistically significant (P> 0.05). Conclusion Automatic blood transfusion in the treatment of neonatal hyperbilirubinemia is safe and effective, and has some impact on the environment in the body, but these effects do not pose a life-threatening risk to the newborn.